Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid
We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting...
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| Veröffentlicht in: | Chemistry of natural compounds 2011, Vol.46 (6), p.841-847 |
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| container_title | Chemistry of natural compounds |
| container_volume | 46 |
| creator | Proteau-Gagne, A. St-Jean, F. Morin, C. Gendron, L. Rousseau, E. Dory, Y. L. |
| description | We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting tone and on bronchi pre-contracted with methacholine. |
| doi_str_mv | 10.1007/s10600-011-9765-z |
| format | Article |
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| ispartof | Chemistry of natural compounds, 2011, Vol.46 (6), p.841-847 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Cytochrome P-450 Histamine Medicine Organic Chemistry Pharmacy Plant Sciences |
| title | Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid |
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