Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid

Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid

We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry of natural compounds 2011, Vol.46 (6), p.841-847
Hauptverfasser: Proteau-Gagne, A., St-Jean, F., Morin, C., Gendron, L., Rousseau, E., Dory, Y. L.
Format: Artikel
Sprache:eng
Schlagworte:
Cytochrome P-450
Histamine
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting tone and on bronchi pre-contracted with methacholine.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-011-9765-z