4-Hydroxy-2-quinolones. 174. Hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl- 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydro- quinoline-3-carboxylic acid - a new class of opioid receptor antagonists

Hydrochlorides salts of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-di-hydroquinoline-3-carboxylic acid were synthesized as potential biologically active compounds. Pharmacological testing showed promise for using these compounds to develop new highly efficient opioid rece...

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Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-08, Vol.46 (4), p.445-451
Hauptverfasser:	Ukrainets, I. V, Sidorenko, L. V, Davidenko, A. A, Yarosh, A. K
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids Amides Analgesics Chemistry Chemistry and Materials Science opioid receptor antagonists amidation Organic acids Organic Chemistry Pharmacy Quinoline
Online-Zugang:	Volltext
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Zusammenfassung:	Hydrochlorides salts of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-di-hydroquinoline-3-carboxylic acid were synthesized as potential biologically active compounds. Pharmacological testing showed promise for using these compounds to develop new highly efficient opioid receptor antagonists.
ISSN:	0009-3122 1573-8353
DOI:	10.1007/s10593-010-0529-7