Pb/[sup.212]Bi generator for nuclear medicine

Pb/[sup.212]Bi generator for nuclear medicine

A scheme for producing the α-emitters [sup.212]Pb and [sup.212]Bi, to be used in a promising method of diagnostics and therapy in oncology--radioimmunotherapy, is proposed. The technology is based on two generators operating in tandem: [sup.228]Th/[sup.212]Pb and [sup.212]Pb/[sup.212]Bi. The first o...

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Veröffentlicht in:Atomic energy (New York, N.Y.) N.Y.), 2012-04, Vol.111 (6), p.422
Hauptverfasser: Boldyrev, P.P, Bortash, A.I, Zagryadskii, V.A, Zakharov, A.S, Nikolaev, V.I, Proshin, M.A, Chuvilin, D. Yu, Shatrov, A.V, Vesnovskii, S.P
Format: Artikel
Sprache:eng
Schlagworte:
Immunotherapy
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Zusammenfassung:A scheme for producing the α-emitters [sup.212]Pb and [sup.212]Bi, to be used in a promising method of diagnostics and therapy in oncology--radioimmunotherapy, is proposed. The technology is based on two generators operating in tandem: [sup.228]Th/[sup.212]Pb and [sup.212]Pb/[sup.212]Bi. The first one is based on separation from an initial solution containing thorium isotopes and gaseous [sup.220]Rn, which secures the purity of the desired products [sup.212]Pb and [sup.212]Bi. For a [sup.228]Th/[sup.212]Pb model generator, the efficiency of [sup.220]Rn extraction from solution was ~60%. After conditioning, the [sup.212]Pb solution from the [sup.228]Th/[sup.212]Pb generator was used to charge a column, which functioned as a [sup.212]Pb/[sup.212]Bi generator, with a cation exchanger.
ISSN:1063-4258
1573-8205
DOI:10.1007/s10512-012-9513-x