The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study/Kasektik olmayan sistolik kalp yetmezlikli olgularda adiponektin, NT-pro-BNP ve sol ventrikul ejeksiyon fraksiyonu arasindaki iliski: gozlemsel bir calisma

Objective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF). Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients. The study was designed to investigate the possible association of these markers in non-cachectic patients with newly diagnosed systolic heart failure. Methods: Fifty-seven systolic HF patients and 20 matched controls were enrolled in an observational cross-sectional study. Physical and echocardiography examinations were performed and serum Adp, NT-proBNP tumor necrosis factoralpha (TNF-α) levels were measured. Study variables were compared between the groups. Correlation analyses were done and the diagnostic validity of the markers was compared with ROC analysis. Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19 ± 12.9 vs. 7.65 ± 4.6 µg/mL; p