Superoxide scavenging activity of plastoquinone derivative 10

Superoxide scavenging activity of plastoquinone derivative 10

The plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly...

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Veröffentlicht in:Biochemistry (Moscow) 2012-07, Vol.77 (7), p.776
Hauptverfasser: Chistyakov, V.A, Prazdnova, E.V, Gutnikova, L.V, Sazykina, M.A, Sazykin, I.S
Format: Artikel
Sprache:eng
Schlagworte:
Organic acids
Superoxide
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Zusammenfassung:The plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) has the ability to scavenge superoxide anion radical. This ability is manifested both in vitro and in vivo in experiments with the bacterium Escherichia coli. The protective effect of SkQ1 in vivo significantly exceeds that of ascorbic acid. DOI: 10.1134/S0006297912070103 Key words: Skulachev ions, SkQ1, superoxide anion radical, superoxide scavenging activity, E. coli
ISSN:0006-2979
DOI:10.1134/S0006297912070103