Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives
The cyclization of 2-substituted N -arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizin...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-07, Vol.49 (4), p.624-635 |
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| container_title | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
| container_volume | 49 |
| creator | Skrastiņa, I. Baran, A. Muceniece, D. |
| description | The cyclization of 2-substituted
N
-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens,
N
-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines. |
| doi_str_mv | 10.1007/s10593-013-1290-5 |
| format | Article |
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N
-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens,
N
-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.</description><identifier>ISSN: 0009-3122</identifier><identifier>EISSN: 1573-8353</identifier><identifier>DOI: 10.1007/s10593-013-1290-5</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Antiviral agents ; Chemical tests and reagents ; Chemistry ; Chemistry and Materials Science ; Hydrogen peroxide ; Organic Chemistry ; Pharmacy</subject><ispartof>Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2013-07, Vol.49 (4), p.624-635</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-1d70e2bcef480d7d2f2ae55935a43b1c79c8803694c135d67342b80dced3cfa73</citedby><cites>FETCH-LOGICAL-c355t-1d70e2bcef480d7d2f2ae55935a43b1c79c8803694c135d67342b80dced3cfa73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10593-013-1290-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10593-013-1290-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids></links><search><creatorcontrib>Skrastiņa, I.</creatorcontrib><creatorcontrib>Baran, A.</creatorcontrib><creatorcontrib>Muceniece, D.</creatorcontrib><title>Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives</title><title>Chemistry of heterocyclic compounds (New York, N.Y. 1965)</title><addtitle>Chem Heterocycl Comp</addtitle><description>The cyclization of 2-substituted
N
-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens,
N
-bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.</description><subject>Antiviral agents</subject><subject>Chemical tests and reagents</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Hydrogen peroxide</subject><subject>Organic Chemistry</subject><subject>Pharmacy</subject><issn>0009-3122</issn><issn>1573-8353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKs_wNuCV1OTzKbZPZaiVRA8qOeQ5qNN3d1IslbWX2_KehFEchgyvM8w8yB0ScmMEiJuEiW8BkwoYMpqgvkRmlAuAFfA4RhNCCE1BsrYKTpLaZe_glblBK2eh67f2uRTEVzR2c-CYdW8DQ3mWMWh8a3vAmbXHBu_HUwMPoV-69VXaGxhbPR71fu9TefoxKkm2YufOkWvd7cvy3v8-LR6WC4esQbOe0yNIJattXVlRYwwzDFled6cqxLWVItaVxWBeV1qCtzMBZRsnZPaGtBOCZiiq3HuRjVW-s6FPird-qTlAkrOhID6kJr9kcrP2Nbr0Fnnc_8XQEdAx5BStE6-R99mAZISeRAsR8EyC5YHwZJnho1MytluY6PchY_Y5ev_gb4BxZp8eA</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Skrastiņa, I.</creator><creator>Baran, A.</creator><creator>Muceniece, D.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130701</creationdate><title>Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives</title><author>Skrastiņa, I. ; Baran, A. ; Muceniece, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-1d70e2bcef480d7d2f2ae55935a43b1c79c8803694c135d67342b80dced3cfa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antiviral agents</topic><topic>Chemical tests and reagents</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Hydrogen peroxide</topic><topic>Organic Chemistry</topic><topic>Pharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skrastiņa, I.</creatorcontrib><creatorcontrib>Baran, A.</creatorcontrib><creatorcontrib>Muceniece, D.</creatorcontrib><collection>CrossRef</collection><jtitle>Chemistry of heterocyclic compounds (New York, N.Y. 1965)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skrastiņa, I.</au><au>Baran, A.</au><au>Muceniece, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives</atitle><jtitle>Chemistry of heterocyclic compounds (New York, N.Y. 1965)</jtitle><stitle>Chem Heterocycl Comp</stitle><date>2013-07-01</date><risdate>2013</risdate><volume>49</volume><issue>4</issue><spage>624</spage><epage>635</epage><pages>624-635</pages><issn>0009-3122</issn><eissn>1573-8353</eissn><abstract>The cyclization of 2-substituted
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N
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| ispartof | Chemistry of heterocyclic compounds (New York, N.Y. 1965), 2013-07, Vol.49 (4), p.624-635 |
| issn | 0009-3122 1573-8353 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A345277397 |
| source | SpringerNature Journals |
| subjects | Antiviral agents Chemical tests and reagents Chemistry Chemistry and Materials Science Hydrogen peroxide Organic Chemistry Pharmacy |
| title | Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives |
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