Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives

Synthesis of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives

The cyclization of 2-substituted N -arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizin...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-07, Vol.49 (4), p.624-635
Hauptverfasser: Skrastiņa, I., Baran, A., Muceniece, D.
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral agents
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Hydrogen peroxide
Organic Chemistry
Pharmacy
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Zusammenfassung:The cyclization of 2-substituted N -arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new 2-alkyl-5-arylimino-2,5-dihydroisothiazole derivatives containing a benzoyl or ester group at position 4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens, N -bromosuccinimide, hydrogen peroxide. Some of the isothiazoles obtained in this work exhibited cytotoxic activity against both normal and cancer cell lines.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1290-5