Synthesis of Calcium Glycinate and the Effects of Its Oral Administration on Biochemical Measures of Bone Metabolism in Mice and Rats

Synthesis of Calcium Glycinate and the Effects of Its Oral Administration on Biochemical Measures of Bone Metabolism in Mice and Rats

The complex Ca(Gly) 2 was synthesized and the chemical composition and structure of this chelate were studied. The possibility of using this calcium glycinate complex as a regulator of bone tissue metabolism was studied in development of experimental osteoporosis in mice and during healing of rat ti...

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Veröffentlicht in:Pharmaceutical chemistry journal 2013-06, Vol.47 (3), p.146-150
Hauptverfasser: Luneva, S. N., Nakoskin, A. N., Vaganova, L. A.
Format: Artikel
Sprache:eng
Schlagworte:
Alfacalcidol
Calcifediol
Fractures
Glycine
Medicine
Organic Chemistry
Osteoporosis
Pharmacology/Toxicology
Pharmacy
Physiological aspects
Vitamin D
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Zusammenfassung:The complex Ca(Gly) 2 was synthesized and the chemical composition and structure of this chelate were studied. The possibility of using this calcium glycinate complex as a regulator of bone tissue metabolism was studied in development of experimental osteoporosis in mice and during healing of rat tibial fractures. The data reported here demonstrate the potential for using calcium glycinate as an agent compensating for bone tissue calcium deficiency.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0914-5