Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold
A series of novel pyrazolo[1,5- a ]pyrazine derivatives has been synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-09, Vol.49 (6), p.915-921 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A series of novel pyrazolo[1,5-
a
]pyrazine derivatives has been synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-
a
]-pyrazin-4(5
H
)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-
a
]pyrazin-4(5
H
)-one have been isolated as intermediate compounds. |
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| ISSN: | 0009-3122 1573-8353 |
| DOI: | 10.1007/s10593-013-1326-x |