Synthesis and analgesic activity of 3,5-diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones

Synthesis and analgesic activity of 3,5-diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones

3,5-Diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones were prepared by the reaction of methyl-1-bromocycloheptane carboxylates with zinc and 1,3-diarylprop-2-en-1-ones. The synthesized compounds possessed analgesic activity and exhibited low toxicity.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutical chemistry journal 2013-04, Vol.47 (1), p.40-41
Hauptverfasser: Kirillov, N. F., Makhmudov, R. R., Gavrilov, A. G., Mardanova, L. G., Vakhrin, M. I.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:3,5-Diaryl-2-oxaspiro[5,6]dodec-3-en-1-ones were prepared by the reaction of methyl-1-bromocycloheptane carboxylates with zinc and 1,3-diarylprop-2-en-1-ones. The synthesized compounds possessed analgesic activity and exhibited low toxicity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0892-7