Doxycycline-sensitized solid-phase fluorescence of europium on silica in the presence of surfactants

The effect of the second ligand and surfactant micelles on the solid-phase time-resolved fluorescence of europium sensitized by doxycycline on Silasorb 600 is studied. A procedure of the sorption-luminescence determination of doxycycline using micelles of Triton X-100 nonionic surfactant is developed; the detection limit is 1.1 × 10 −7 . The analytical range for doxycycline is 3 × 10 −7 to 3 × 10 −5 M. The procedure is tested on a doxycycline pharmaceutical drug; RSD was no worse than 4%.