The CCND1 c.870GA polymorphism is a risk factor for t multiple myeloma

The CCND1 c.870GA polymorphism is a risk factor for t multiple myeloma

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyo-type. The t(11;14)(q13;q3...

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Veröffentlicht in:Nature genetics 2013-05, Vol.45 (5), p.522
Hauptverfasser: Weinhold, Niels, Johnson, David C, Chubb, Daniel, Chen, Bowang, Forsti, Asta, Hosking, Fay J, Broderick, Peter, Ma, Yussanne P, Dobbins, Sara E, Hose, Dirk, Walker, Brian A, Davies, Faith E, Kaiser, Martin F, Li, Ni L, Gregory, Walter A, Jackson, Graham H, Witzens-Harig, Mathias, Neben, Kai, Hoffmann, Per, Nothen, Markus M, Muhleisen, Thomas W, Eisele, Lewin, Ross, Fiona M, Jauch, Anna, Goldschmidt, Hartmut, Houlston, Richard S, Morgan, Gareth J, Hemminki, Kari
Format: Artikel
Sprache:eng
Schlagworte:
Genetic aspects
Health aspects
Immunoglobulins
Multiple myeloma
Risk factors
Single nucleotide polymorphisms
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Zusammenfassung:A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyo-type. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x [10.sup.-11]). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
ISSN:1061-4036
1546-1718