J Pediatr Gastroenterol Nutr: diagnosis of coeliac disease in children younger than 2 years

BACKGROUND AND AIM: To diagnose coeliac disease (CD) in children younger than 2 years, the old ESPGHAN criteria based on 3 small bowel biopsies were recommended until recently. The aim of the present study was to investigate the applicability of only 1 small intestinal biopsy plus positive serology...

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Veröffentlicht in:Croatian medical journal 2013-02, Vol.54 (1), p.98
Hauptverfasser: Misak, Z, Hojsak, I, Jadresin, O, Kekez, A.J, Abdovic, S, Kolacek, S
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Sprache:eng
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Zusammenfassung:BACKGROUND AND AIM: To diagnose coeliac disease (CD) in children younger than 2 years, the old ESPGHAN criteria based on 3 small bowel biopsies were recommended until recently. The aim of the present study was to investigate the applicability of only 1 small intestinal biopsy plus positive serology for the diagnosis of CD in children younger than 2 years. METHODS: A prospective cohort study included 81 patients younger than 2 years with symptoms suggestive of CD, who all completed the diagnostic procedure based on 3 small bowel biopsies. According to the finding of the third biopsy, patients were divided into group A-CD confirmed (N=44), and group B-CD not confirmed, after the gluten challenge (N=37). RESULTS: At the time of the first biopsy, total villous atrophy (Marsh IIIc) was found more often in group A than in group B (77% vs 27%, P
ISSN:0353-9504