A case with fever of unknown origin diagnosed as wegener granulomatosis / Wegener granulomatozis tans konulan bir nedeni bilinmeyen ates olgusu

Fever of unknown origin (FUO) was described in 1961 by Petersdorf and Beeson as a fever above 38.3[degrees]C that lasts more than three weeks and cannot be diagnosed despite a one-week hospitalized examination. In 1991, Durack and Street made a different FUO description for patients with nosocomial infections, human immunodeficiency virus (HIV) and neutropenia. Along with this reconsideration, the investigation period was limited to one week of investigation, three days of hospitalization or three clinical visits. In the literature, the most frequent cause of FUO is infections followed by neoplasms and connective vascular diseases, respectively. The etiology in 5-15% of patients can not be diagnosed despite detailed examination. Here, we present a 75-year-old patient admitted to the hospital with a two-week history of fever, fatigue and lack of appetite. He had been examined in the infection and lung diseases clinics over a three-month period without diagnosis. In our internal medicine clinic, we diagnosed the patient as Wegener granulomatosis and a satisfactory response to the therapy was observed. (Turk J Rheumatol 2010; 25: 159-61) Key words: Fever, proteinuria, wegener granulomatosis Received: 08.09.2008 Accepted: 08.10.2008 Nedeni bilinmeyen ates (NBA), 1961 yilinda Petersdorf ve Beeson tarafindan 3 haftadan uzun suren, 1 haftalik hastanede inceleme sonrasinda nedeni bulunamayan, 38,3 derecenin uzerinde ates yuksekligi olarak tanimlanmistir. Durack ve Street tarafindan 1991'de nazokomiyal enfeksiyonlar, HIV, notropenik hastalarda ayri ayri nedeni bilinmeyen ates tanimlamalari yapilmis, bu tanimlamayla klasik NBA tanimlamasinda yer alan 1 haftalik tetkik suresi, 3 klinik vizit ya da 3 gunluk hastane yatisiyla sinirlandirilmistir. NBA 'in literaturde bildirilen en sik sebebi enfeksiyonlar olup bunu neoplazmlar ve kollajen vaskuler hastaliklar izlemektedir. Tum incelemelere ragmen % 5-15 hastanin ates etyolojisi aydinlatilamamaktadir. Bu yazida 2 haftadir kontrol edileme-yen ates, halsizlik, istahsizlik, yakinmalariyla doktora basvuran, 75 yasindaki bir olguyu sunmaktayiz. 3 ay sureyle enfeksiyon hastaliklari, gogus hastaliklari kliniklerinde yapilan genis incelemelerle ates etyolojisi aydinlatilmaya calisilmis, ic hastaliklari kliniginde nedeninin Wegener Granulomatozis oldugu saptanip, tedaviye yuzguldurucu yanit gozlenmistir (Turk J Rheumatol 2010; 25: 159-61) Anahtar sozcukler: Ates, proteinuri, wegener granulomatozis Alindigi Tarih: 08.09.2008 Kabul