Molecular epidemiology of Mycobacterium tuberculosis transmission between cattle and man--a case report/Molekularna epidemiologija infekcije vrstom Mycobacterium tuberculosis u goveda i ljudi--prikaz slucaja

We describe a case of transmission of Mycobacterium (M.) tuberculosis infection from a man to cattle. M. tuberculosis was isolated from the bronchial lymph nodes of a heifer that reacted positively to bovine tuberculin but showed no gross pathological changes at slaughter. The cattle owner died of tuberculosis the same year the heifer was diagnosed with M. tuberculosis infection. M. tuberculosis strains isolated from the heifer and its owner were genotyped by mycobacterial interspersed repetitive units--variable-number tandem repeat (MIRU-VNTR) typing, which revealed identical MIRU profiles for both isolates. This is the first described case of M. tuberculosis infection in cattle and the first case of human-to-animal transmission of M. tuberculosis in Croatia. Key words: Mycobacterium tuberculosis, cattle, Croatia Opisan je slucaj prijenosa zaraze vrstom Mycobacterium (M.) tuberculosis s covjeka na govedo. M tuberculosis je izdvojen iz bronhalnih limfnih cvorova junice koja je pozitivno reagirala na tuberkulin, a prilikom klanja nisu utvrdene patomorfoloske promjene karakteristicne za tuberkulozu. Iste godine vlasnik goveda je preminuo od posljedica tuberkuloze. Izolati M. tuberculosis iz goveda i covjeka bili su genotipizirani pomocu metode odredivanja promjenjivog broja opetovanih sljedova nukleotida (engl. mycobacterial interspersed repetitive units--variable-number tandem repeat [MIRU-VNTR]) i u oba je slucaja bio utvrden identican rezultat genotipizacije. Ovo je prvi opisani slucaj zaraze vrstom M. tuberculosis u goveda i prvi slucaj prijenosa ove bolesti s covjeka na govedo u Hrvatskoj. Kjucne rijeci: Mycobacterium tuberculosis, govedo, Hrvatska