Distribution of hepatitis C virus genotypes in haemodialysis patients of Guilan, northern Islamic Republic of Iran/Repartition des genotypes du virus de l'hepatite C chez des patients hemodialyses a Guilan (Nord de la Republique islamique d'Iran)
[TEXT NOT REPRODUCIBLE IN ASCII.] The incidence of hepatitis C virus (HCV) infection among patients undergoing haemodialysis is high. The aim of this study was to identify the HCV genotypes among chronic haemodialysis patients who were HCV positive in Guilan province, northern Islamic Republic of Ir...
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Veröffentlicht in: | Eastern Mediterranean health journal 2012-03, Vol.18 (3), p.236 |
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Zusammenfassung: | [TEXT NOT REPRODUCIBLE IN ASCII.] The incidence of hepatitis C virus (HCV) infection among patients undergoing haemodialysis is high. The aim of this study was to identify the HCV genotypes among chronic haemodialysis patients who were HCV positive in Guilan province, northern Islamic Republic of Iran. All patients on haemodialysis at Guilan haemodialysis centres were enrolled. Enzyme-linked immunosorbent assay and polymerase chain reaction testing were performed. Out of 514 enrolled patients, 11.9% were serologically HCV positive and 6.2% had positive HCV-RNA. HCV genotypes were determined with HCV genotype-specific primers. The most frequent genotypes were 1a (59.4%) and 3a (40.6%). There was no significant relationship between virus genotypes and sex or age. The HCV genotype pattern among haemodialysis patients in Guilan province was different from other countries of the Middle East and was more similar to North American and European countries where genotype 1 is predominant. L'incidence de l'infection par le virus de l'hepatite C chez les patients hemodialyses est elevee. La presente etude visait a identifier les genotypes du virus de l'hepatite C chez des patients hemodialyses infectes dans la province de Guilan (Nord de la Republique islamique d'Iran). Tous les patients hemodialyses dans les centres specialises de Guilan ont ete recrutes. Un test immuno-enzymatique et une amplification en chame par polymerase ont ete realises. Sur 514 patients recrutes, 11,9 % etaient serologiquement positifs au virus de l'hepatite C et 6,2 % etaient positifs a l'ARN-VHC. Les genotypes du virus de l'hepatite C ont ete determines avec des amorces specifiques de genotypes du virus. Les genotypes 1a (59,4 %) et 3a (40,6 %) etaient les plus frequents. Aucune relation significative n'a ete retrouvee entre les genotypes du virus et le sexe ou l'age des patients. La repartition des genotypes du virus de l'hepatite C chez les patients hemodialyses dans la province de Guilan etait differente de celle des autres pays du Moyen-Orient. Elle ressemblait davantage a la repartition observee en Amerique du Nord et dans les pays europeens ou le genotype 1 predomine. |
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ISSN: | 1020-3397 1020-3397 |