A possible association?: ulcerative colitis and familial Mediteranean fever/Olasi bir iliski: ulseratif kolit ve ailevi Akdeniz atesi

Epidemiological studies have revealed a higher prevalence of inflammatory bowel disease in patients with familial Mediterranean fever (FMF). FMF and ulcerative colitis are two inflammatory disorders and are both characterized by a recurrent attacks, remission and neutrophilic infiltration at the site of injury. The FMF gene (MEFV) encodes a protein, marenostrin or pyrin, expressed in mature granulocytes. Marenostrin probably has an important role in the down regulation of inflammatory response. Inflammatory bowel disease, ulcerative colitis and Crohn's disease are frequently associated with MEFV gene mutations. We report a patient who was synchronously diagnosed with ulcerative colitis and FMF. (The Medical Bulletin of Haseki 2010; 48: 53-5) Key Words: Ulcerative colitis, familial mediteranean fever, steroid Epidemiyolojik calismalar ailesel Akdeniz atesi tanisi olan hastalarda inflamatuvar barsak hastaligi sikliginin yuksek oldugunu gostermistir. Her iki hastaligin da, farkli histopatolojik bulgular olsa da, inflamatuvar ozellik tasidigi bilinir ve tekrarlayan ataklar, remisyon ve hasarli alanlarda notrofilik infiltrasyon ile karakterizedir. Ailevi Akdeniz atesi ile iliskili gen (MEFV) olgun granulositlerden salgilanan ve marenostrin ya da pyrin isimli bir protein araciligi ile inflamasyonu kontrol altinda tutar. Inflamatuvar barsak hastaligi yani ulseratif kolit ve Crohn hastaligi, MEFV geni ile siklikla iliskilidir. Biz bu yazida, ulseratif kolit ve ailevi Akdeniz atesi tanisini es zamanli olarak koydugumuz bir olguyu sunduk. (Haseki Tip Bulteni 2010; 48: 53-5) Anahtar Kelimeler: Ulseratif kolit, ailevi akdeniz atesi, steroit