Psychiatric adverse effects of dermatological drugs/Dermatolojik ilaclarin psikiyatrik yan etkileri

Dermatological drugs, mostly corticosteroids and isotretinoin, cause different psychiatric adverse effects. During steroid therapy, a wide range of psychiatric conditions, from minor clinical symptoms like insomnia and anxiety to serious psychiatric syndromes like psychosis and delirium might be seen. In medical literature, a causal connection is usually suggested between "isotretinoin", which is used for treatment of acne vulgaris and depression and suicide attempts. However, there are no statistically significant double-blind randomized studies that support this connection. Clinicians must know patient's psychiatric history before using any dermatological treatment known as causing psychiatric adverse effects, and psychiatric consultation should be established whenever necessary. (Turkderm 2010; 44 Suppl 1: 52-4) Key Words: Dermatological drugs, psychiatry, isotretinoin, corticosteroids Kortikosteroidler ve isotretinoin basta olmak uzere dermatolojik tedavide kullanilan ilaclarin farkli psikiyatrik yan etkileri bulunmaktadir. Steroid kullanimi esnasinda uykusuzluk, anksiyete gibi gorece basit semptomlardan psikoz ve deliryum gibi daha ciddi psikiyatrik sorunlara kadar degisebilen farkli klinik tablolar gozlenebilir. Akne vulgaris tedavisinde kullanilan isotretinoin, literaturde siklikla depresyon ve intihar girisimlerinin nedeni olarak one surulmustur. Ancak bu iliski acisindan istatistiksel olarak anlamli bulgular iceren cift kor randomize bir calisma bulunmamaktadir. Psikiyatrik yan etkiye neden olabilecek dermatolojik ilaclarin kullanimi oncesinde hastanin psikiyatrik oykusu alinmali, tedavi surecinde gerektiginde psikiyatrik konsultasyon istenmelidir. (Turkderm 2010; 44 Ozel Sayi 1: 52-4) Anahtar Kelimeler: Dermatolojik ilaclar, psikiyatri, isotretinoin, kortikosteroidler