Chlamydia trachomatis and cervical intraepithelial neoplasia in married women in a middle eastern community/Les infections a Chlamydia trachomatis et la neoplasie cervicale intraepithelial chez les femmes mariees d'une communaute du Moyen-Orient

The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia (CIN). Data were collected in a case-control study for 60 patients with CIN in biopsy and 85 control subjects with normal colposcopy and biopsy. Serum antibodies to C. trachomatis were associated with an increased risk for CIN [odds ratio (OR) = 7.3; 95% confidence interval (CI) 1.5-35.2)]. There was also a significant association between presence of inclusion bodies for C. trachomatis and CIN (OR = 5.5; 95% CI 2.4-12.4). These results indicate a strong association between CIN and chlamydial cervicitis. L'objectif de cette etude etait de determiner la relation entre les infections vaginales a Chlamydia et la neoplasie cervicale intraepithelial (CIN). Des donnees ont ete collectees lors d'une etude cas-temoin portant sur 60 patientes dont la biopsie confirmait une CIN et un groupe temoin de 85 personnes dont la colposcopie et la biopsie etaient normales. Les anticorps seriques anti-C. trachomatis etaient associes a une augmentation du risque de CIN (odds ratio = 7,3; intervalle de confiance (IC) 95 % 1,5 - 35,2)]. Une association significative a egalement ete observee entre la presence de corps d'inclusion de C. trachomatis et la CIN (odds ratio= 5,5; IC 95 % 2,4 - 12,4). Ces resultats indiquent une association importante entre la CIN et une cervicite a Chlamydia.