Covalently conjugation of Genistein with biodegradable Poly L-Lactide

A novel drug (Genistein) conjugated biodegradable polymer (PLLA) was synthesized by the direct coupling of Genistein with Poly L-Lactide (GEN-PLLA) and was characterized by FTIR, HPLC and GPC study. These results indicate that the unique property of bound Genistein has an inhibiting influence on the...

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Veröffentlicht in:	Trends in biomaterials & artificial organs 2010-01, Vol.23 (3), p.145
Hauptverfasser:	Sojitra, Prakash, Raval, Ankur, Kothwala, Devesh, Kotadia, Haresh, Adeshara, Subodhchandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation Equipment and supplies Materials Medical equipment Medical equipment and supplies industry Medical test kit industry Physiological apparatus Plastics Product development Tissue engineering
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Zusammenfassung:	A novel drug (Genistein) conjugated biodegradable polymer (PLLA) was synthesized by the direct coupling of Genistein with Poly L-Lactide (GEN-PLLA) and was characterized by FTIR, HPLC and GPC study. These results indicate that the unique property of bound Genistein has an inhibiting influence on the coagulation, plasma protein adsorption, and subsequent platelet adhesion systems. This novel GEN-PLLA conjugate could be applied as blood/tissue compatible biodegradable materials for implantable medical devices and tissue engineering, especially to medical devices like coronary stents. [C] Society for Biomaterials and Artificial Organs (India), 20090220-38.
ISSN:	0971-1198