MHC class II-dependent basophil-[CD4.sup.+] T cell interactions promote [T.sub.H]2 cytokine-dependent immunity
Dendritic cells can prime naive [CD4.sup.+] T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility comple...
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| Veröffentlicht in: | Nature immunology 2009-07, Vol.10 (7), p.697 |
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| creator | Perrigoue, Jacqueline G Saenz, Steven A Siracusa, Mark C Allenspach, Eric J Taylor, Betsy C Giacomin, Paul R Nair, Meera G Du, Yurong Zaph, Colby van Rooijen, Nico Comeau, Michael R Pearce, Edward J Laufer, Terri M Artis, David |
| description | Dendritic cells can prime naive [CD4.sup.+] T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific [CD4.sup.+] T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive [CD4.sup.+] T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II-dependent interactions between basophils and [CD4.sup.+] T cells promote T helper type 2 cytokine responses and immunity to helminth infection. |
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We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific [CD4.sup.+] T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive [CD4.sup.+] T cells in vivo. 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We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific [CD4.sup.+] T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive [CD4.sup.+] T cells in vivo. 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| subjects | Basophils Cell interaction Genetic aspects Health aspects Helminthiasis Immune response Physiological aspects Risk factors T cells |
| title | MHC class II-dependent basophil-[CD4.sup.+] T cell interactions promote [T.sub.H]2 cytokine-dependent immunity |
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