MHC class II-dependent basophil-[CD4.sup.+] T cell interactions promote [T.sub.H]2 cytokine-dependent immunity

Dendritic cells can prime naive [CD4.sup.+] T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility comple...

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Veröffentlicht in:Nature immunology 2009-07, Vol.10 (7), p.697
Hauptverfasser: Perrigoue, Jacqueline G, Saenz, Steven A, Siracusa, Mark C, Allenspach, Eric J, Taylor, Betsy C, Giacomin, Paul R, Nair, Meera G, Du, Yurong, Zaph, Colby, van Rooijen, Nico, Comeau, Michael R, Pearce, Edward J, Laufer, Terri M, Artis, David
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Zusammenfassung:Dendritic cells can prime naive [CD4.sup.+] T cells; however, here we demonstrate that dendritic cell-mediated priming was insufficient for the development of T helper type 2 cell-dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific [CD4.sup.+] T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive [CD4.sup.+] T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II-dependent interactions between basophils and [CD4.sup.+] T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
ISSN:1529-2908