What turns on Foxp3? Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression

Bibliographische Detailangaben

Veröffentlicht in:	Nature immunology 2008-02, Vol.9 (2), p.121
Hauptverfasser:	von Boehmer, Harald, Nolting, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases DNA binding proteins Health aspects Physiological aspects Prevention T cells Transforming growth factors
Online-Zugang:	Volltext
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