Projected Impact of Implementing the Results of the Diabetes Prevention Program in the U.S. Population

Projected Impact of Implementing the Results of the Diabetes Prevention Program in the U.S. Population Sharon H. Saydah , PHD, MHS 1 , Danita Byrd-Holt 1 and Maureen I. Harris , PHD, MPH 2 1 Social and Scientific Systems, Silver Spring, Maryland 2 National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland Abstract OBJECTIVE —To determine the feasibility of using either fasting plasma glucose or HbA 1c to identify individuals in the U.S. population who meet the Diabetes Prevention Program (DPP) criteria for intervention, defined as BMI ≥24 kg/m 2 , fasting plasma glucose level 96–125 mg/dl, and 2-h glucose level 140–199 mg/dl in an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS —Analysis of a representative sample of U.S. adults aged 40–74 years with no medical history of diabetes for whom data on height, weight, fasting plasma glucose, HbA 1c , and 2-h plasma glucose during an OGTT were obtained. Sensitivity, specificity, positive predictive value (PPV), and receiver operator characteristic (ROC) curves for fasting glucose and HbA 1c were determined. RESULTS —Using BMI