Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19.sup.- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD1...

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Veröffentlicht in:	Nature Medicine 2018, Vol.24 (10), p.1499
Hauptverfasser:	Ruella, Marco, Xu, Jun, Barrett, David M, Fraietta, Joseph A, Reich, Tyler J, Ambrose, David E, Klichinsky, Michael
Format:	Report
Sprache:	eng
Schlagworte:	Antigenic determinants Antigens B cells Cancer recurrence Case studies Chemotherapy Complications and side effects Genes Health aspects Leukemia Medical schools Production management Recurrence (Disease) T cell antigen receptors T cells
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