Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19.sup.- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature Medicine 2018, Vol.24 (10), p.1499
Hauptverfasser: Ruella, Marco, Xu, Jun, Barrett, David M, Fraietta, Joseph A, Reich, Tyler J, Ambrose, David E, Klichinsky, Michael
Format: Report
Sprache:eng
Schlagworte:
Antigenic determinants
Antigens
B cells
Cancer recurrence
Case studies
Chemotherapy
Complications and side effects
Genes
Health aspects
Leukemia
Medical schools
Production management
Recurrence (Disease)
T cell antigen receptors
T cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19.sup.- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to CTL019.
ISSN:1078-8956
DOI:10.1038/s41591-018-0201-9