Response to Ethanol Reduced by past Thiamine Deficiency

Ethanol-induced intoxication and hypothermia were studied in rats approximately 7 months after severe thiamine deficiency, when treated rats appeared to have recovered their physical health. Previously induced thiamine deficiency without prior ethanol exposure significantly decreased the area under...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1985-03, Vol.227 (4692), p.1365-1368
Hauptverfasser:	Martin, Peter R., Majchrowicz, Edward, Tamborska, Ewa, Marietta, Cheryl, Mukherjee, Anil B., Eckardt, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol abuse Alcohol Amnestic Disorder - pathology Alcoholic beverages Alcoholic intoxication Alcoholic Intoxication - physiopathology Alcoholism Alcoholism and acute alcohol poisoning Animals Behavior, Animal - drug effects Biological and medical sciences Body Temperature - drug effects Brain Brain - pathology Ethanol Ethanol - pharmacology Female Health aspects Humans Hypothermia Hypothermia - chemically induced Korsakoff syndrome Laboratory rats Male Mating behavior Medical sciences Metabolism Nervous system diseases Rats Rats as laboratory animals Rats, Inbred Strains Thiamine deficiency Thiamine Deficiency - physiopathology Toxicology Vitamin B1 deficiency Wernicke Encephalopathy - pathology Wernicke's encephalopathy
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Beschreibung
Zusammenfassung:	Ethanol-induced intoxication and hypothermia were studied in rats approximately 7 months after severe thiamine deficiency, when treated rats appeared to have recovered their physical health. Previously induced thiamine deficiency without prior ethanol exposure significantly decreased the area under the curve plotted for the concentration of ethanol in blood and also decreased behavioral impairment and hypothermia due to ethanol exposure. Pathophysiologic changes resulting from thiamine deficiency may contribute to both the pharmacodynamic and pharmacokinetic tolerance to ethanol in chronic alcoholics.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.3975622