Identification of an Erythrocyte Component Carrying the Duffy Blood Group Fy$^{\text{a}}$ Antigen

Identification of an Erythrocyte Component Carrying the Duffy Blood Group Fy$^{\text{a}}$ Antigen

The erythrocyte component carrying the Duffy blood group antigen Fy$^{a}$ has been identified as a 35- to 43-kilodalton protein. The protein is degraded by proteases, chymotrypsin, and Pronase, which destroy its antigenicity on intact erythrocytes. Its unusual property of aggregating on being boiled...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1984-02, Vol.223 (4636), p.597-599
Hauptverfasser: Hadley, Terence J., David, Peter H., McGinniss, Mary H., Miller, Louis H.
Format: Artikel
Sprache:eng
Schlagworte:
ABO blood-group system
Agglutination
Antigen-antibody reactions
Antigens
Blood groups
Erythrocyte membrane
Erythrocytes
Gels
Immunologic research
Immunological research
Molecular weight
Molecules
Observations
Parasitic diseases
Parasitological research
Reactivity
Room temperature
Sodium
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Beschreibung
Zusammenfassung:The erythrocyte component carrying the Duffy blood group antigen Fy$^{a}$ has been identified as a 35- to 43-kilodalton protein. The protein is degraded by proteases, chymotrypsin, and Pronase, which destroy its antigenicity on intact erythrocytes. Its unusual property of aggregating on being boiled in 5 percent sodium dodecyl sulfate with 5 percent 2-mercaptoethanol distinguishes it from other erythrocyte membrane proteins described to date.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6695171