Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats
The aim of this study was to investigate the synergistic hepatoprotective effect of lignans from Fructus Schisandrae chinensis (LFS) with Astragalus polysaccharides (APS) on chronic liver injury in male Sprague-Dawley rats. Subcutaneous injection of 10% CCl 4 twice a week for 3 months resulted in si...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2009-09, Vol.16 (9), p.805-813 |
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| creator | Yan, Fei Zhang, Qiao-Yan Jiao, Lei Han, Ting Zhang, Hong Qin, Lu-Ping Khalid, Rahman |
| description | The aim of this study was to investigate the synergistic hepatoprotective effect of lignans from
Fructus Schisandrae chinensis (LFS) with
Astragalus polysaccharides (APS) on chronic liver injury in male Sprague-Dawley rats. Subcutaneous injection of 10% CCl
4 twice a week for 3 months resulted in significantly (
p |
| doi_str_mv | 10.1016/j.phymed.2009.02.004 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracgeneralonefile_A221083834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A221083834</galeid><els_id>S0944711309000397</els_id><sourcerecordid>A221083834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-510d31295795280cd9a57b0e75ece2f3344ed6b26019641d6263fe3d17ac88fd3</originalsourceid><addsrcrecordid>eNp9kd2KFDEQhYMo7uzqG4jkBbq38tN_N8KwuCoseLEK3oVMUpnO0JM0Sc9K-_RmmMWrRXJRITnnVCUfIR8Y1AxYe3uo53E9oq05wFADrwHkK7JhLesrGJpfr8kGBimrjjFxRa5zPgAwOXTwllyxQcgGumZD_jyuAdPe58UbOuKslzinuKBZ_BNSdK7saHT00Yw-62CTRjr5fdAh099-Gek2L0nv9XTKdI7TmrUxo07eYqYxUDOmGEryVNIS9eFwSmspNOklvyNvnJ4yvn-uN-Tn_ecfd1-rh-9fvt1tHyojRbdUDQMrGB-abmh4D8YOuul2gF2DBrkTQkq07Y63wIZWMtvyVjgUlnXa9L2z4oZUl9wyJSofXCwTmz2Wd-spBnS-HG85Z9CLXsiir1_Ql2Xx6M2LBnkxmBRzTujUnPxRp1UxUGdW6qAurNSZlQKuCqti-3ixzafd-e6f6RlOEXy6CLD8zpPHpLLxGAxanwoWZaP_f4e_c6mpcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yan, Fei ; Zhang, Qiao-Yan ; Jiao, Lei ; Han, Ting ; Zhang, Hong ; Qin, Lu-Ping ; Khalid, Rahman</creator><creatorcontrib>Yan, Fei ; Zhang, Qiao-Yan ; Jiao, Lei ; Han, Ting ; Zhang, Hong ; Qin, Lu-Ping ; Khalid, Rahman</creatorcontrib><description><![CDATA[The aim of this study was to investigate the synergistic hepatoprotective effect of lignans from
Fructus Schisandrae chinensis (LFS) with
Astragalus polysaccharides (APS) on chronic liver injury in male Sprague-Dawley rats. Subcutaneous injection of 10% CCl
4 twice a week for 3 months resulted in significantly (
p<0.001) elevated serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) activities compared to controls. In the liver, significantly elevated levels (
p<0.001) of malondialdehyde (MDA), lowered levels of reduced glutathione (GSH) (
p<0.05) and catalase (CAT) (
p<0.001), superoxide dismutase (SOD) (
p<0.01)were observed following CCl
4 administration. ‘LFS+ASP’ treatment of rats at doses of ‘LFS (45
mg/kg)+APS (150
mg/kg)’ and ‘LFS (135
mg/kg)+APS (450
mg/kg)’ displayed hepatoprotective and antioxidative effects than the administration of either LFS or APS, as evident by lower (
p<0.005 or 0.001) levels of serum ALT, AST, ALP and hepatic MDA (
p<0.001) concentration, as well as higher SOD (
p<0.05 or 0.005), CAT activities(
p<0.01 or 0.005), GSH concentration (
p<0.05 or 0.005) compared to the toxin treated group. Histopathological examinations revealed severe fatty degeneration in the toxin group, and mild damage in groups treated with ‘LFS+APS’ were observed. The coefficients drug interaction (CDI) between each individual drug and their combination (at the same dose of their single treatment) of these foregoing parameters were all less than 1, indicating that LFS and APS display hepatoprotective and antioxidant properties and act in a synergistic manner in CCl
4 induced liver injury in rats.]]></description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2009.02.004</identifier><identifier>PMID: 19345075</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Astragalus (Plants) ; Astragalus membranaceus ; Astragalus polysaccharides ; Carbon Tetrachloride ; Care and treatment ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - pathology ; Chemical properties ; Chronic Disease ; Drug Synergism ; Drug Therapy, Combination ; Enzymes - blood ; Fatty Liver - prevention & control ; Fructus Schisandrae chinensis ; Fruit ; Health aspects ; Hepatoprotective ; Lignans - pharmacology ; Lignans - therapeutic use ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Liver diseases ; Male ; Malondialdehyde - blood ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Polysaccharides - pharmacology ; Polysaccharides - therapeutic use ; Protective Agents - pharmacology ; Protective Agents - therapeutic use ; Rats ; Rats, Sprague-Dawley ; Rattus ; Schisandra ; Synergistic</subject><ispartof>Phytomedicine (Stuttgart), 2009-09, Vol.16 (9), p.805-813</ispartof><rights>2009 Elsevier GmbH</rights><rights>COPYRIGHT 2009 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-510d31295795280cd9a57b0e75ece2f3344ed6b26019641d6263fe3d17ac88fd3</citedby><cites>FETCH-LOGICAL-c437t-510d31295795280cd9a57b0e75ece2f3344ed6b26019641d6263fe3d17ac88fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711309000397$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19345075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Fei</creatorcontrib><creatorcontrib>Zhang, Qiao-Yan</creatorcontrib><creatorcontrib>Jiao, Lei</creatorcontrib><creatorcontrib>Han, Ting</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Qin, Lu-Ping</creatorcontrib><creatorcontrib>Khalid, Rahman</creatorcontrib><title>Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description><![CDATA[The aim of this study was to investigate the synergistic hepatoprotective effect of lignans from
Fructus Schisandrae chinensis (LFS) with
Astragalus polysaccharides (APS) on chronic liver injury in male Sprague-Dawley rats. Subcutaneous injection of 10% CCl
4 twice a week for 3 months resulted in significantly (
p<0.001) elevated serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) activities compared to controls. In the liver, significantly elevated levels (
p<0.001) of malondialdehyde (MDA), lowered levels of reduced glutathione (GSH) (
p<0.05) and catalase (CAT) (
p<0.001), superoxide dismutase (SOD) (
p<0.01)were observed following CCl
4 administration. ‘LFS+ASP’ treatment of rats at doses of ‘LFS (45
mg/kg)+APS (150
mg/kg)’ and ‘LFS (135
mg/kg)+APS (450
mg/kg)’ displayed hepatoprotective and antioxidative effects than the administration of either LFS or APS, as evident by lower (
p<0.005 or 0.001) levels of serum ALT, AST, ALP and hepatic MDA (
p<0.001) concentration, as well as higher SOD (
p<0.05 or 0.005), CAT activities(
p<0.01 or 0.005), GSH concentration (
p<0.05 or 0.005) compared to the toxin treated group. Histopathological examinations revealed severe fatty degeneration in the toxin group, and mild damage in groups treated with ‘LFS+APS’ were observed. The coefficients drug interaction (CDI) between each individual drug and their combination (at the same dose of their single treatment) of these foregoing parameters were all less than 1, indicating that LFS and APS display hepatoprotective and antioxidant properties and act in a synergistic manner in CCl
4 induced liver injury in rats.]]></description><subject>Animals</subject><subject>Astragalus (Plants)</subject><subject>Astragalus membranaceus</subject><subject>Astragalus polysaccharides</subject><subject>Carbon Tetrachloride</subject><subject>Care and treatment</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Chemical properties</subject><subject>Chronic Disease</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Enzymes - blood</subject><subject>Fatty Liver - prevention & control</subject><subject>Fructus Schisandrae chinensis</subject><subject>Fruit</subject><subject>Health aspects</subject><subject>Hepatoprotective</subject><subject>Lignans - pharmacology</subject><subject>Lignans - therapeutic use</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - therapeutic use</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - therapeutic use</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rattus</subject><subject>Schisandra</subject><subject>Synergistic</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2KFDEQhYMo7uzqG4jkBbq38tN_N8KwuCoseLEK3oVMUpnO0JM0Sc9K-_RmmMWrRXJRITnnVCUfIR8Y1AxYe3uo53E9oq05wFADrwHkK7JhLesrGJpfr8kGBimrjjFxRa5zPgAwOXTwllyxQcgGumZD_jyuAdPe58UbOuKslzinuKBZ_BNSdK7saHT00Yw-62CTRjr5fdAh099-Gek2L0nv9XTKdI7TmrUxo07eYqYxUDOmGEryVNIS9eFwSmspNOklvyNvnJ4yvn-uN-Tn_ecfd1-rh-9fvt1tHyojRbdUDQMrGB-abmh4D8YOuul2gF2DBrkTQkq07Y63wIZWMtvyVjgUlnXa9L2z4oZUl9wyJSofXCwTmz2Wd-spBnS-HG85Z9CLXsiir1_Ql2Xx6M2LBnkxmBRzTujUnPxRp1UxUGdW6qAurNSZlQKuCqti-3ixzafd-e6f6RlOEXy6CLD8zpPHpLLxGAxanwoWZaP_f4e_c6mpcg</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Yan, Fei</creator><creator>Zhang, Qiao-Yan</creator><creator>Jiao, Lei</creator><creator>Han, Ting</creator><creator>Zhang, Hong</creator><creator>Qin, Lu-Ping</creator><creator>Khalid, Rahman</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090901</creationdate><title>Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats</title><author>Yan, Fei ; Zhang, Qiao-Yan ; Jiao, Lei ; Han, Ting ; Zhang, Hong ; Qin, Lu-Ping ; Khalid, Rahman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-510d31295795280cd9a57b0e75ece2f3344ed6b26019641d6263fe3d17ac88fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Astragalus (Plants)</topic><topic>Astragalus membranaceus</topic><topic>Astragalus polysaccharides</topic><topic>Carbon Tetrachloride</topic><topic>Care and treatment</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - pathology</topic><topic>Chemical properties</topic><topic>Chronic Disease</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Enzymes - blood</topic><topic>Fatty Liver - prevention & control</topic><topic>Fructus Schisandrae chinensis</topic><topic>Fruit</topic><topic>Health aspects</topic><topic>Hepatoprotective</topic><topic>Lignans - pharmacology</topic><topic>Lignans - therapeutic use</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - therapeutic use</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - therapeutic use</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rattus</topic><topic>Schisandra</topic><topic>Synergistic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Fei</creatorcontrib><creatorcontrib>Zhang, Qiao-Yan</creatorcontrib><creatorcontrib>Jiao, Lei</creatorcontrib><creatorcontrib>Han, Ting</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Qin, Lu-Ping</creatorcontrib><creatorcontrib>Khalid, Rahman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Fei</au><au>Zhang, Qiao-Yan</au><au>Jiao, Lei</au><au>Han, Ting</au><au>Zhang, Hong</au><au>Qin, Lu-Ping</au><au>Khalid, Rahman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>16</volume><issue>9</issue><spage>805</spage><epage>813</epage><pages>805-813</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract><![CDATA[The aim of this study was to investigate the synergistic hepatoprotective effect of lignans from
Fructus Schisandrae chinensis (LFS) with
Astragalus polysaccharides (APS) on chronic liver injury in male Sprague-Dawley rats. Subcutaneous injection of 10% CCl
4 twice a week for 3 months resulted in significantly (
p<0.001) elevated serum alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) activities compared to controls. In the liver, significantly elevated levels (
p<0.001) of malondialdehyde (MDA), lowered levels of reduced glutathione (GSH) (
p<0.05) and catalase (CAT) (
p<0.001), superoxide dismutase (SOD) (
p<0.01)were observed following CCl
4 administration. ‘LFS+ASP’ treatment of rats at doses of ‘LFS (45
mg/kg)+APS (150
mg/kg)’ and ‘LFS (135
mg/kg)+APS (450
mg/kg)’ displayed hepatoprotective and antioxidative effects than the administration of either LFS or APS, as evident by lower (
p<0.005 or 0.001) levels of serum ALT, AST, ALP and hepatic MDA (
p<0.001) concentration, as well as higher SOD (
p<0.05 or 0.005), CAT activities(
p<0.01 or 0.005), GSH concentration (
p<0.05 or 0.005) compared to the toxin treated group. Histopathological examinations revealed severe fatty degeneration in the toxin group, and mild damage in groups treated with ‘LFS+APS’ were observed. The coefficients drug interaction (CDI) between each individual drug and their combination (at the same dose of their single treatment) of these foregoing parameters were all less than 1, indicating that LFS and APS display hepatoprotective and antioxidant properties and act in a synergistic manner in CCl
4 induced liver injury in rats.]]></abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>19345075</pmid><doi>10.1016/j.phymed.2009.02.004</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2009-09, Vol.16 (9), p.805-813 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_gale_infotracgeneralonefile_A221083834 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Astragalus (Plants) Astragalus membranaceus Astragalus polysaccharides Carbon Tetrachloride Care and treatment Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - pathology Chemical properties Chronic Disease Drug Synergism Drug Therapy, Combination Enzymes - blood Fatty Liver - prevention & control Fructus Schisandrae chinensis Fruit Health aspects Hepatoprotective Lignans - pharmacology Lignans - therapeutic use Liver - drug effects Liver - enzymology Liver - pathology Liver diseases Male Malondialdehyde - blood Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Polysaccharides - pharmacology Polysaccharides - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Rattus Schisandra Synergistic |
| title | Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats |
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