Histamine: Putative Transmitter for Lateral Inhibition in Limulus Eye

Histamine: Putative Transmitter for Lateral Inhibition in Limulus Eye

Electrophysiological and pharmacological studies were conducted on the effect of histamine on the lateral inhibition in the eye of the horseshoe crab. Tests were made to determine whether histamine imitates the action of lateral inhibition on optic nerve activity generated by eccentric cells. In add...

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Veröffentlicht in:The Biological bulletin (Lancaster) 1997-10, Vol.193 (2), p.203-205
Hauptverfasser: Stewart, K. M., Porcello, D. M., McSweeney, M. E., Saito, T., Passaglia, C. L., Dodge, F. A., Barlow, R. B.
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials
Animals
Cimetidine - pharmacology
Crustaceans
Electrophysiology
Eye
Eyes & eyesight
Histamine
Histamine - pharmacology
Histamine - physiology
Histamine H2 Antagonists - pharmacology
Horseshoe Crabs
Inhibition
Inhibition (Psychology)
Limulus
Marine
Marine biology
Neural Inhibition
Ocular Physiological Phenomena - drug effects
Pharmacology
Physiological aspects
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Beschreibung
Zusammenfassung:Electrophysiological and pharmacological studies were conducted on the effect of histamine on the lateral inhibition in the eye of the horseshoe crab. Tests were made to determine whether histamine imitates the action of lateral inhibition on optic nerve activity generated by eccentric cells. In addition, the role of histamine receptor blocker cimetidine was also tested in the lateral inhibition of eccentric cell responses. These tests revealed that histamine is the mediator of lateral inhibition in the eye of horseshoe crabs.
ISSN:0006-3185
1939-8697
DOI:10.1086/BBLv193n2p203