One-pot synthesis of β-amido ketones using Brønsted acidic ionic liquid as an efficient and reusable catalyst

An efficient protocol was developed for one-pot condensation of an aldehyde, ketone, acetyl chloride, and nitriles catalyzed by a stable and reusable 1-methyl-imidazolium hydrogen sulfate ([Hmim][HSO 4 ]) as a Brønsted acidic ionic liquid. The system tolerated a variety of functional groups affording the corresponding β-amido ketones in moderate to good yields under milder operating conditions.