Impact of Differences in Fasting Glucose and Glucose Tolerance on the Hyperbolic Relationship Between Insulin Sensitivity and Insulin Responses

Impact of Differences in Fasting Glucose and Glucose Tolerance on the Hyperbolic Relationship Between Insulin Sensitivity and Insulin Responses Kristina M. Utzschneider , MD 1 , Ronald L. Prigeon , MD 2 , Darcy B. Carr , MD 3 , Rebecca L. Hull , PHD 1 , Jenny Tong , MD 1 , Jane B. Shofer , MS 4 , Barbara M. Retzlaff , RN 1 , Robert H. Knopp , MD 1 and Steven E. Kahn , MB, CHB 1 1 Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 2 Geriatric Research, Education and Clinical Center, Baltimore VA Medical Center and Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland 3 Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Washington, Seattle, Washington 4 Rehabilitation, Research and Development Center, VA Puget Sound Health Care System, Seattle, Washington Address correspondence and reprint requests to Kristina M. Utzschneider, MD, VA Puget Sound Health Care System (151), 1660 S. Columbian Way, Seattle, WA 98108. E-mail: kutzschn{at}u.washington.edu Abstract OBJECTIVE —To determine whether the hyperbolic relationship between insulin sensitivity and the acute insulin response to glucose (AIR g ) exists in subjects with impaired fasting glucose (IFG) or decreased glucose tolerance. RESEARCH DESIGN AND METHODS —We studied 219 healthy subjects (88 male and 131 female subjects, aged 26–75 years) with fasting plasma glucose (FPG)