THI and TH2 cell antigen receptors in experimental leishmaniasis

The complexity and chronicity of parasitic infections have obscured the identification of biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice infected with Leishmania major revealed the expansion of a restricted population of [CD.4.sup.+] cells. These cels expressed the V [alpha]8-J[alpha].TA72 V[beta]4 in both progressive infection and protective immunity and across several major histocompatibility haplotypes. Thus, then same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals.