Alzheimer's Disease: The Amyloid Cascade Hypothesis

Alzheimer's disease causes dementia and is characterized by various pathological markers in the brain. A hypothesis that deposition of amyloid beta protein is the causative agent of Alzheimer's pathology and that the neurofibrillary tangles, cell loss, vascular damage and dementia are a di...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-04, Vol.256 (5054), p.184-185
Hauptverfasser:	Hardy, John A., Higgins, Gerald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - etiology Alzheimer Disease - genetics Alzheimer Disease - physiopathology Alzheimer's disease Alzheimers Disease Amyloid - genetics Amyloid - metabolism Amyloid - physiology Amyloid beta-Protein Precursor - genetics Amyloids Biological and medical sciences Brain Brain - pathology Brain - physiopathology Calcium Causes of Cell Death Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Down Syndrome Etiology Genetic mutation Humans Medical research Medical sciences Metabolic diseases Molecules Multidisciplinary Sciences Mutation Nervous system diseases Neurofibrillary tangles Neurofibrillary Tangles - physiology Neurology Neurons Pathology Perspective Protein metabolism Proteins Science & Technology Science & Technology - Other Topics
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Beschreibung
Zusammenfassung:	Alzheimer's disease causes dementia and is characterized by various pathological markers in the brain. A hypothesis that deposition of amyloid beta protein is the causative agent of Alzheimer's pathology and that the neurofibrillary tangles, cell loss, vascular damage and dementia are a direct result of the protein is examined.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1566067