Obesity Is an Independent Prognostic Factor That Reduced Pathological Complete Response in Operable Breast Cancer Patients

Obesity Is an Independent Prognostic Factor That Reduced Pathological Complete Response in Operable Breast Cancer Patients

Background and Objectives: Obesity is a significant risk factor for the development of breast cancer (BC) and associated poorer outcomes. A pathological complete response (pCR) with neoadjuvant chemotherapy (NACT) correlates with improved long-term prognosis in BC patients. In this study, we aimed t...

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Veröffentlicht in:Medicina 2024, Vol.60 (12)
Hauptverfasser: Guliyev, Murad, Alan, Özkan, Günaltılı, Murat, Safarov, Shamkhal, Fidan, Mehmet Cem, Alkan Şen, Gülin, Değerli, Ezgi, Papila, Berrin, Demirci, Nebi Serkan, Papila, Çiğdem
Format: Report
Sprache:eng
Schlagworte:
Adjuvant treatment
Body mass index
Breast cancer
Cancer
Cancer patients
Care and treatment
Development and progression
Health aspects
Medical research
Medicine, Experimental
Menopause
Obesity
Pertuzumab
Postmenopausal women
Risk factors
Women
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Zusammenfassung:Background and Objectives: Obesity is a significant risk factor for the development of breast cancer (BC) and associated poorer outcomes. A pathological complete response (pCR) with neoadjuvant chemotherapy (NACT) correlates with improved long-term prognosis in BC patients. In this study, we aimed to investigate the predictive effect of obesity on achieving pCR following NACT. Methods: This single-center retrospective study included patients with operable BC who were treated with NACT. Patients were categorized based on their pre-chemotherapy body mass index (BMI), including non-obese (
ISSN:1648-9144
DOI:10.3390/medicina60121953