S[sub.N]Ar Reactions on 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde

S[sub.N]Ar Reactions on 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde

We report the experimental results of unexpected aromatic nucleophilic substitution reaction products on 2-amino-4,6-dichloropyrimidine-5-carbaldehyde. The isolated compounds are products of amination, solvolysis, and condensation processes under mild and environmentally friendly conditions, due to...

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Veröffentlicht in:MolBank 2022-08, Vol.2022 (3)
Hauptverfasser: Trilleras, Jorge, Pérez-Gamboa, Alfredo, Quiroga, Jairo
Format: Artikel
Sprache:eng
Schlagworte:
Amino compounds
Analysis
Identification and classification
Infrared spectroscopy
Methods
Pyrimidines
Structure
Substitution reactions
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Zusammenfassung:We report the experimental results of unexpected aromatic nucleophilic substitution reaction products on 2-amino-4,6-dichloropyrimidine-5-carbaldehyde. The isolated compounds are products of amination, solvolysis, and condensation processes under mild and environmentally friendly conditions, due to the influence of structural factors of the starting pyrimidine and a high concentration of alkoxide ions. This method allows the building of pyrimidine-based compound precursors of N-heterocyclic systems.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1426