Synthesis and Properties of C,N-Chelated Carbene Complexes of PaHadium with 2-Aminobenzo[d]thiazole Fragment

The reaction of bis(cyclohexylisocyanide) complex of Pd(II) with substituted benzo[d]thiazole-2-amines in the presence of triethanolamine as the base has lead to the formation of deprotonated C,N-chelated carbene complexes with a structure similar to that described previously for the products of the reaction with unsubstituted benzo[d]thiazole-2-amine. The complexes have been isolated and characterized using high-resolution mass spectrometry, IR and NMR spectroscopy ([sup.1]H, [sup.13]C{[sup.1]H}, [sup.1]H-[sup.1]H COSY, [sup.1]H-[sup.1]H NOESY, [sup.1]H- [sup.13]C HSQC, [sup.1]H-[sup.13]C HMBC). The resulting complexes have exhibited moderate antibacterial activity against sensitive strains of gram-negative bacteria E. coli (C600) and P. fluorescens (P218), gram-positive bacteria S. aureus (ATCC-25923) and B. subtillis (B-3142D) as well as fungi C. albicans (401/NCTC-885-653). Keywords: acyclic diaminocarbene complexes, palladium chelate complexes, isocyanide ligands, antimicrobial activity, benzo[d]thiazole-2-amines DOI: 10.1134/S1070363219100128