S.sub.N.sup.HAr Reaction of Pyridines with Bisphosphonates Assisted by Electron-Deficient Acetylenes

The S.sub.N.sup.HAr reaction of pyridines with bis(polyfluoroalkyl)phosphonates assisted by benzoylphenylacetylene (equimolar reactants ratio, 70-75°Ð¡, 3.5-7 h, catalyst- and solvent-free) has led to bis(polyfluoroalkyl)pyridinylphosphonates in yield up to 51%. In the presence of phenylcyanoacetylene, pyridine has reacted with bis(2,2,2-trifluoroethyl)phosphonate at room temperature to regio- and stereoselectively form Z-(cyanophenylethenyl)-1,4-dihydropyridin-4-ylphosphonate, the S.sub.N.sup.HAr reaction kinetic product, in high yield.