Synthesis and Antinociceptive Activity of Substituted 5-hydrazono-3H-furan-2-ones

Synthesis and Antinociceptive Activity of Substituted 5-hydrazono-3H-furan-2-ones

The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compound...

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Veröffentlicht in:Russian journal of general chemistry 2021-12, Vol.91 (12), p.2469
Hauptverfasser: Lipin, D. V, Denisova, E. I, Devyatkin, I. Ð, Okoneshnikova, Ð. Ð, Shipilovskikh, D. A, Makhmudov, R. R, Igidov, N. M
Format: Artikel
Sprache:eng
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Zusammenfassung:The method was proposed for the synthesis of new substituted 5-(het)aryl-3-(4-methylbenzoyl)hydrazono-3H-furan-2-ones by intramolecular cyclization of 2-[2-(4-methylbenzoyl)hydrazono]-4-oxobut-2-enoic acids in the presence of propionic anhydride. The antinociceptive activity of the obtained compounds was studied.
ISSN:1070-3632
DOI:10.1134/S1070363221120161