The Prognostic Importance of Neutrophil--to--Lymphocyte Ratio and Platelet--to--Lymphocyte Ratio in Adult Patients with Sepsis Who Underwent Hemoperfusion in General Intensive Care Unit

Objective: Sepsis is a major cause of mortality and morbidity in the intensive care units. The goal of this study is to investigate whether changes in the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are a prognostic marker for patients with sepsis (according to sepsis stages, and patient's and disease's characteristics) who have been followed up in the intensive care unit and who have received HA330 resin-directed hemadsorption column for sepsis. Methods: The study included a group of 100 (male [healed: 19, exitus: 42], female [cured: 29, exitus: 10]) sepsis patients who were followed up in the intensive care unit between December 2019 and December 2021 and who received HA-330 sepsis adsorption column. Results: Although a strong positive correlation was found between the neutrophil-to-lymphocyte ratio and the baseline platelet-to-lymphocyte ratio values (r = 0.725 and P = .001), a weak positive correlation was found between the baseline neutrophil-to-lymphocyte ratio and the comorbidity values (r = 0.253 and P = .001). In addition, the period found for hemoperfusion in those who healed was statistically significantly higher in exitus patients (P = .001). It was noted that the improvement in repeated neutrophil-to-lymphocyte ratio measurements in the healing and death observations was identical (P > .05). The repeated neutrophil-to-lymphocyte ratio measurement values were found to be statistically significantly different for those with healing (P = .014). In addition, repeated neutrophil-to-lymphocyte ratio measurement values were found to be statistically significantly different from those with exitus (P = .001). It was observed that the change of repeated platelet-to-lymphocyte ratio measurements in the observations with healing and death was statistically significant (P < .05). Conclusion: It is thought that it may be a cheap and useful biomarker in the prognosis of patients who are followed up in the intensive care unit and are treated with HA-330 sepsis adsorption column since the rate of neutrophils and lymphocytes in patients with hematological healing and death difers greatly. Keywords: Sepsis, hemoperfusion, neutrophils, lymphocytes, blood platelets, ratio, intensive care units