Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong

Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong

We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025...

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Veröffentlicht in:Emerging infectious diseases 2021-12, Vol.27 (12), p.3036-3044
Hauptverfasser: Guo, Cosmos L. T., Kwong, Thomas N. Y., Mak, Joyce W. Y., Zhang, Lin, Lui, Grace C. Y., Wong, Grace L. H., Ip, Margaret, Yu, Jun, Sung, Joseph J. Y., Wu, William K. K., Wong, Sunny H.
Format: Artikel
Sprache:eng
Schlagworte:
Clostridium infections
Hospital patients
Immunology
Infectious Diseases
Life Sciences & Biomedicine
Patient outcomes
Risk factors
Science & Technology
Statistics
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Zusammenfassung:We conducted a territorywide survey to investigate the epidemiology, risk factors, and clinical outcomes of Clostridioides difficile infection (CDI) among hospitalized patients in Hong Kong. A total of 17,105 cases of CDI were identified, of which 15,717 (91.9%) were healthcare-associated and 1,025 (6.0%) were community-associated. Although CDI incidence increased substantially from 2006 to 2017, it plateaued in 2018 and 2019. The 30-day mortality rates decreased from 20.1% in 2015 to 16.8% in 2019, whereas the 60-day recurrence rates remained constant at approximate to 11% during the study period. Cross-correlation statistic showed significant correlations between incidence trend and overall antimicrobial drug use (r = 0.865, p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2712.213769