Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation

Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation

Background: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT). Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid gr...

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Veröffentlicht in:International Journal of General Medicine 2021, Vol.14, p.5711
Hauptverfasser: Salman, Ahmed, Aon, Mohamed, Hussein, Amr, Salman, Mohamed, Tourky, Mohamed, Mahmoud, Ahmed, Aljarad, Feras, Elkaseer, Mohamed, Shaaban, Hossam El-Din, Moustafa, Ahmed, El-Mikkawy, Ahmed, Gaballa, Nahla, Abdallah, Heba, Zaky Rashed, Zaky Ftouh, Elkassar, Hesham
Format: Report
Sprache:eng
Schlagworte:
Donation of organs, tissues, etc
Egypt
Health aspects
Hepatoma
Hypothyroidism
Liver
Medical research
Medicine, Experimental
Mortality
Risk factors
Thyroid hormones
Transplantation
United Kingdom
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Zusammenfassung:Background: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT). Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS). Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p
ISSN:1178-7074
1178-7074