Development of a Quantitative Determination Method for a Benzimidazole Derivative with Laboratory Code RU-31 and Antimigraine Activity in Biological Samples

Development of a Quantitative Determination Method for a Benzimidazole Derivative with Laboratory Code RU-31 and Antimigraine Activity in Biological Samples

A quantitative determination method for drug substance RU-31, a derivative of a methoxyphenylimidazo - [1,2-α]benzimidazole possessing antimigraine activity, in biological samples was developed. This method has selectivity and high sensitivity sufficient to allow its use for pharmacokinetic studies...

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Veröffentlicht in:Pharmaceutical chemistry journal 2021-06, Vol.55 (3), p.312-314
Hauptverfasser: Smirnova, L. A., Ryabukha, A. F., Kuznetsov, K. A., Velikopolskaya, M. V., Spasov, A. A., Yakovlev, D. S.
Format: Artikel
Sprache:eng
Schlagworte:
Medicine
Methods
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Ruthenium
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Zusammenfassung:A quantitative determination method for drug substance RU-31, a derivative of a methoxyphenylimidazo - [1,2-α]benzimidazole possessing antimigraine activity, in biological samples was developed. This method has selectivity and high sensitivity sufficient to allow its use for pharmacokinetic studies of RU-31. The sensitivity of the method (detection limit) for RU-31 is 100 ng/mL; limit of quantitation, 500 ng/mL. The average measurement error is ≤15%.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-021-02418-9