Crizotinib-Associated Renal Cysts in Anaplastic Lymphoma Kinase-Positive Lung Cancer Patients: A Single-Center Experience

Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor that was approved for ALK-harboring lung cancer. There have been reports about the development and progression of renal cysts from crizotinib. We report a series of 3 cases of crizotinib-associated renal cysts in patients admitted to our in...

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Veröffentlicht in:	Urologia internationalis 2020-05, Vol.104 (3-4), p.269-272
Hauptverfasser:	Eiamprapaporn, Panuch, Mungwatthana, Naphapatt, Twinprai, Prin, Sookprasert, Aumkhae, Chindaprasirt, Jarin, Ahooja, Anucha, Watthanaudomrot, Sirinthip, Sirithanaphol, Wichien
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anaplastic Lymphoma Kinase - biosynthesis Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Case studies Causes of Complications and side effects Crizotinib Crizotinib - adverse effects Crizotinib - therapeutic use Cysts Drug therapy Female Humans Kidney diseases Kidney Diseases, Cystic - chemically induced Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Male Original Paper Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use
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Zusammenfassung:	Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor that was approved for ALK-harboring lung cancer. There have been reports about the development and progression of renal cysts from crizotinib. We report a series of 3 cases of crizotinib-associated renal cysts in patients admitted to our institution, with different kinds of presentation. A monitor for complex renal cysts is warranted in patients receiving crizotinib.
ISSN:	0042-1138 1423-0399
DOI:	10.1159/000502664