Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy

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Veröffentlicht in:	LEUKEMIA 2021-03, Vol.35 (3), p.863-866
Hauptverfasser:	Østergaard, Anna, Bohnstedt, Cathrine, Grell, Kathrine, Degn, Matilda, Zeller, Bernward, Taskinen, Mervi, Hafsteinsdottir, Solveig, Björgvinsdóttir, Helga, Heyman, Mats, Hoogerbrugge, Peter, Schmiegelow, Kjeld
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 6-Mercaptopurine 631/67/1059/99 631/67/1990/283/2125 82/16 Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Antineoplastic Combined Chemotherapy Protocols - metabolism Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Research Case-Control Studies Child Child, Preschool Critical Care Medicine Cytotoxicity Development and progression DNA methylation Down syndrome Down Syndrome - drug therapy Down Syndrome - metabolism Down Syndrome - mortality Down Syndrome - pathology Down's syndrome Drug dosages Drug therapy Enzymes Female Follow-Up Studies Hematology Humans Infant Intensive Internal Medicine Letter Leukemia Life Sciences & Biomedicine Lymphatic leukemia Maintenance Chemotherapy - mortality Male Medical research Medicin och hälsovetenskap Medicine Medicine & Public Health Mercaptopurine Mercaptopurine - administration & dosage Metabolites Methotrexate Methotrexate - administration & dosage Oncology Patient outcomes Pediatrics Pharmacodynamics Physiological aspects Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Science & Technology Survival Rate
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ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/s41375-020-0946-2