Protein-Sorption and the Hemostatic Properties of Composite Materials Based on Polyurethane Foam Filled with Silicon and Aluminum Oxides

An effective hemostatic composite material was obtained due to the combination of water-absorption, protein-sorption, and hemostatic properties of highly dispersed oxides of SiO 2 and Al 2 O 3 with the cellular structure of polyurethane foam. It was found that a sample with a silica content of 5 wt.% has the highest parameters of osmotic activity and water absorption. The protein-adsorption activity of the fillers in the composite is slightly reduced, but remains at a level sufficient for the manifestation of biological activity. The hemostatic effect of the composite materials was studied in a model of parenchymal bleeding in rats.