Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants

Combination of gamma-glutamyl transferase and liver stiffness measurement for biliary atresia screening at different ages: a retrospective analysis of 282 infants

Background This study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages. Methods Our retrospective study involved 282 infants under the age of 120 days with jaundic...

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Veröffentlicht in:BMC pediatrics 2020-06, Vol.20 (1), p.276-276, Article 276
Hauptverfasser: Shen, Qiulong, Tan, Sarah Siyin, Wang, Zengmeng, Cai, Siyu, Pang, Wenbo, Peng, Chunhui, Chen, Yajun
Format: Artikel
Sprache:eng
Schlagworte:
Age groups
Analysis
Biliary atresia
Biliary Atresia - diagnosis
Child
Gallbladder diseases
gamma-Glutamyltransferase
Health aspects
Humans
Infant
Infantile cholestatic jaundice
Infants
Life Sciences & Biomedicine
Liver
Liver - diagnostic imaging
Measurement
Medical prognosis
Misdiagnosis
Parallel test
Patients
Pediatrics
Phosphatase
Regression analysis
Retrospective Studies
ROC Curve
Science & Technology
Statistical analysis
Surgery
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Zusammenfassung:Background This study aims to explore the diagnostic accuracy of the combination of gamma-glutamyl transferase (GGT) and liver stiffness measurement (LSM) for biliary atresia (BA) screening at different ages. Methods Our retrospective study involved 282 infants under the age of 120 days with jaundice who were admitted into Beijing Children's Hospital between January 2016 to December 2018. The GGT and LSM levels of infants were obtained. A parallel test was used, and ROC curve was created to obtain cutoff values of GGT and LSM for BA infants at different ages. Results Of the 282 infants, 135 were diagnosed with BA and 147 were non-BA infants. In all age groups (A:
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-020-02172-z