Dinitrodibenzo [B,D]Oxepin-7(6h)-One Antiproliferative Activity Against Hepg2 Cells

The cytotoxic activity of twenty three new biphenyl compounds was investigated, and the IC 50 value of 1,2-dinitrodibenzo [b,d]oxepin-7(6H)-one (DNDBO) was found to be the lowest among these compounds. The underlying mechanism of DNDBO-induced cell death was explored.

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Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical chemistry journal 2019-10, Vol.53 (7), p.624-627
Hauptverfasser:	Li, Qiang, Sun, ShaoPing, Gong, XianFeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell death Ethylenediaminetetraacetic acid Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The cytotoxic activity of twenty three new biphenyl compounds was investigated, and the IC 50 value of 1,2-dinitrodibenzo [b,d]oxepin-7(6H)-one (DNDBO) was found to be the lowest among these compounds. The underlying mechanism of DNDBO-induced cell death was explored.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-019-02050-8