Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

Synthesis of C5-C6 Derivatives of 1,3-Dimethyl-5-Fluorouracil and 5-Fluorouracil. Screening for Antiviral Activity

5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl 2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human...

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Veröffentlicht in:Pharmaceutical chemistry journal 2019-05, Vol.53 (2), p.108-112
Hauptverfasser: Chernikova, I. B., Khursan, S. L., Eropkin, M. Yu, Yunusov, M. S.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Antineoplastic agents
Antiviral agents
Fluorouracil
Influenza
Influenza viruses
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Pyrimidines
Search for New Drugs
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Zusammenfassung:5-Chloro-5-fluoro-6-alkoxypyrimidines were synthesized via Cl 2 chlorination of 5-fluorouracil and 1,3-dimethyl-5-fluorouracil in various alcohols and were screened for antiviral activity. High antiviral activity was found for 5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil against RS virus and human flu viruses A/H3N2 and A/H1N1pdm09.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-01962-9